Adrian Raiche, Ph.D. Named as Director of Formulation Development at Coldstream Laboratories, Inc.
In order to effectively develop a lyophilization cycle, it is important to understand the glass transition temperature (through Differential Scanning Calorimetry “DSC”) and collapse temperature (through Freeze-Drying Microscopy “FDM”) of the formulation between the liquid, glassy, and frozen states. These values will help define the maximum product temperature that the product can achieve during primary drying in order to prevent collapse or melt back of the product due to incomplete sublimation of unbound moisture and/or solvent. This should happen prior to the ramp to secondary drying with final removal of the bound moisture and/or solvent.
In April of 2012, Coldstream Laboratories expanded its sales presence to the West Coast with the addition of Heidi Kipers as Business Development Manager. As Coldstream’s West Coast sales representative, Heidi is based in San Diego, CA, and represents the territory west of the Rocky Mountains.
(Lexington, KY—(Marketwire—July 24, 2012) - Coldstream Laboratories, Inc., a Lexington, Kentucky, based pharmaceutical and biotechnology development and manufacturing firm announced today the initiation of significant enhancements to its manufacturing facility. Work began last week on expanding a number of key systems in the sterile drug product manufacturing plant aimed at improving efficiencies and expanding capacity to produce parenteral products.