Pharmaceutical grade water is the most commonly used ingredient in sterile pharmaceutical manufacturing and acceptable water purity is critical to producing quality final drug product. Water for Injection (WFI) is water that is purified by distillation or a purification process that is equivalent or superior to distillation in the removal of chemicals and microorganisms. Pharmaceutical manufacturers are moving from laboratory to on-line analysis for real time water release. Real-time release can greatly improve efficiencies and cost while allowing for increased quality assurance awareness. Real-time release of pharmaceutical waters increases system understanding, decreases QC testing, reduces batch risk and improves process controls.